Diablo3
Diablo3 won´t be an all new game, because the previous parts of the game , part one and two, had to be respected while developing the new game. There´s such a big community playing and knowing the older games, that blizzard couldn´t change the whole thing. So only things like the interaction between environment and player have changed and also the use of life potions.
Especially the last named thing has changed radically, because you don´t have to use your inventory every time you want to heal yourself. Instead of the old system of healing, the new one in Diablo3 is based on dropping “life balls” from some enemies.
That means for the player, the bothersome collecting of those potions has an end. Sure the player has to collect potions but not in values like in part two, where half of the inventory was filled with them. Another new thing around diablo3 i, how you can change your situation within a battle using the enviroment. For example you can throw parts of a wall on your enemies to smash them, with using some of your special skills.
A great “plus” in diablo3 is the free turnable camera, to see your character from different angles and to see the beautifully made environment. Especially the environment was improved really hard with detailing it more than ever and its moving and influencing the gameplay. Also there are new, more interesting, traps in which your characters can tap withou thinking about.